Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p38 | Bone biomechanics and quality | ECTS2016

Arthritis induces early bone structural degradation and mechanical weakness

Vidal Bruno , Cascao Rita , Finnila Mikko , Lopes Ines , Saarakkala Simo , Canhao Helena , Fonseca Joao

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...